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. 2020 Feb 20;69(6):939–950. doi: 10.1007/s00262-020-02501-2

Table 1.

PK parameters of IBI101 after single intravenous injection of 0.1, 0.5, 2.5 and 12.5 mg/kg in cynomolgus macaques (mean ± SD, n = 6)

Parameters Units Dose of IBI101
0.1 mg/kg 0.5 mg/kg 2.5 mg/kg 12.5 mg/kg
Cmax µg/mL 3.07 ± 0.40 9.78 ± 3.27 63.10 ± 15.29 296.57 ± 58.05
Tmax h 0.08 ± 0.00 0.40 ± 0.78 0.08 ± 0.00 0.40 ± 0.78
AUC0-∞ h × µg/mL 347.98 ± 99.30 1429.19 ± 607.21 10,304.06 ± 3403.59 33,511.65 ± 14,982.36
t1/2 H 162.98 ± 103.01 129.47 ± 114.44 190.89 ± 92.94 120.30 ± 153.26
Cl mL/h/kg 0.31 ± 0.08 0.40 ± 0.14 0.27 ± 0.09 0.44 ± 0.20
MRTlast h 186.34 ± 110.68 136.03 ± 108.05 212.29 ± 114.61 114.93 ± 87.66

Values are mean ± SD

Cmax maximum drug concentration observed in serum, AUC0–∞, area under the concentration–time curve from time zero to the last measurable concentration, t1/2 effective half-time, which was calculated by terminal phase data harvested, MRTlast mean reaction time from time zero to the last measurable concentration