Table 1.

PK parameters of IBI101 after single intravenous injection of 0.1, 0.5, 2.5 and 12.5 mg/kg in cynomolgus macaques (mean ± SD, n = 6)

Parameters	Units	Dose of IBI101
		0.1 mg/kg	0.5 mg/kg	2.5 mg/kg	12.5 mg/kg
Cmax	µg/mL	3.07 ± 0.40	9.78 ± 3.27	63.10 ± 15.29	296.57 ± 58.05
Tmax	h	0.08 ± 0.00	0.40 ± 0.78	0.08 ± 0.00	0.40 ± 0.78
AUC0-∞	h × µg/mL	347.98 ± 99.30	1429.19 ± 607.21	10,304.06 ± 3403.59	33,511.65 ± 14,982.36
t1/2	H	162.98 ± 103.01	129.47 ± 114.44	190.89 ± 92.94	120.30 ± 153.26
Cl	mL/h/kg	0.31 ± 0.08	0.40 ± 0.14	0.27 ± 0.09	0.44 ± 0.20
MRTlast	h	186.34 ± 110.68	136.03 ± 108.05	212.29 ± 114.61	114.93 ± 87.66

Values are mean ± SD

C_max maximum drug concentration observed in serum, AUC_0–∞, area under the concentration–time curve from time zero to the last measurable concentration, t_1/2 effective half-time, which was calculated by terminal phase data harvested, MRT_last mean reaction time from time zero to the last measurable concentration