Table 2.

PK parameters of IBI101 after Multiple Intravenous Injections at 2.5 mg/kg (mean ± SD, n = 6)

Parameters	Units	Study day
		Day 1	Day 22
Cmax	µg/mL	51.23 ± 12.19	86.88 ± 19.72
Tmax	h	1.72 ± 3.17	1.72 ± 3.17
AUC0–∞	h × µg/mL	7912.74 ± 3297.42	21,048.42 ± 10,074.99
t1/2	h	140.81 ± 28.50	178.92 ± 117.23
Cl	mL/h/kg	0.37 ± 0.16	0.40 ± 0.72
MRTlast	h	67.42 ± 3.10	262.91 ± 124.94

Values are mean ± SD

C_max maximum drug concentration observed in serum, AUC_0–∞ area under the concentration–time curve from time zero to the last measurable concentration, t_1/2 effective half-time, which was calculated by terminal phase data harvested, MRT_last mean reaction time from time zero to the last measurable

concentration