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. 2020 May 18;69(10):2041–2051. doi: 10.1007/s00262-020-02608-6

Table 3.

Cox univariate and multivariate analysis of prognostic parameters for OS and PFS of patients with clear cell RCC (n = 69)

Prognostic parameter Univariate analysis Multivariate analysis
HR 95% CI P value HR 95% CI P value
Overall survival
 Stage (I, II vs III, IV) 5.474 1.198–25.010 0.028 3.062 0.579–16.190 0.188
 Grade (1, 2 vs 3) 3.002 0.796–11.330 0.105 1.565 0.354–6.929 0.555
 CD8 (low vs high) 2.278 0.685–7.573 0.179
 Foxp3 (low vs high) 1.437 0.460–4.495 0.533
 PD-L1 (low vs high) 4.418 1.374–14.210 0.013 2.122 0.538–8.366 0.282
 PD-L2 (low vs high) 1.664 0.501–5.527 0.406
 B7-H4 (low vs high) 1.637 0.519–5.162 0.400
 Galectin-9 (low vs high) 4.043 1.283–12.740 0.017 3.330 0.921–12.040 0.067
Progression-free survival
 Stage (I, II vs III, IV) 12.450 3.744–41.420  < 0.001 9.987 2.881–34.610  < 0.001
 Grade (1, 2 vs 3) 4.194 1.727–10.190 0.002 2.155 0.835–5.564 0.113
 CD8 (low vs high) 1.444 0.686–3.038 0.333
 Foxp3 (low vs high) 1.052 0.489–2.265 0.896
 PD-L1 (low vs high) 1.968 0.787–4.921 0.148
 PD-L2 (low vs high) 1.234 0.520–2.926 0.634
 B7-H4 (low vs high) 2.248 1.025–4.932 0.043 2.227 0.982–5.050 0.055
 Galectin-9 (low vs high) 1.471 0.658–3.287 0.347

HR hazard ratio, CI confidence interval