Fig. 3.

Properties of individual lymphocytic subsets and sTIL density in breast carcinomas. High lymphocytic subset counts/mm² were associated with higher proliferation rate (shown in a) and with high tumor grade (shown in b). Higher sTIL density in HER2-positive tumors irrespectively of hormone receptor positivity and in TNBC (c). Similar distribution patterns were observed for individual lymphocytic subsets, as indicated in d. Hierarchical clustering of continuous counts/mm² yielded two distinct clusters, cluster 1 with low density of all lymphocytic subsets and cluster 2 with high density, respectively (e). Associations of these clusters with patient DFS and OS are shown in f. sL, sH: stromal low, stromal high; iL, iH: intratumoral low and high, respectively; LUMA: luminal-A; LUMB: luminal-B; LUMHER2: luminal-HER2; HER2-en: HER2-entiched