Table 2.
Correlations of PD-L1 and PD-1 expression and TILs' densities with pathological parameters
| Characteristic | Positive PD-L1 TPS (%) | P | Positive PD-L1 CPS (%) | P | Positive PD-1 score (%) | P | CD8+ above median (%) | P | FOXP3+ above median (%) | P |
|---|---|---|---|---|---|---|---|---|---|---|
| Location | ||||||||||
| Oropharynx | 69/231 (30) | .94 | 89/231 (38) | .46 | 107/222 (48) | .56 | 110/225 (49) | .84 | 96/225 (43) | .002 |
| Hypopharynx | 18/60 (30) | 28/59 (47) | 23/55 (42) | 29/57 (51) | 32/57 (56) | |||||
| Larynx | 16/58 (28) | 23/58 (40) | 22/42 (54) | 25/55 (45) | 38/56 (68) | |||||
| pT Classification | ||||||||||
| T1-T2 | 34/102 (33) | .033 | 46/102 (45) | .04 | 40/91(44) | .77 | 50/96 (52) | .45 | 56/97 (58) | .44 |
| T3 | 42/120 (35) | 54/119 (45) | 53/110 (48) | 59/116 (51) | 59/116 (51) | |||||
| T4 | 26/127 (20) | 39/124 (31) | 56/115 (49) | 54/122 (44) | 50/122 (41) | |||||
| pN Classification | ||||||||||
| N0 | 31/90 (34) | .28 | 40/90 (44) | .38 | 36/78 (46) | .79 | 47/87 (54) | .26 | 44/88 (50) | .9 |
| N1–3 | 72/259 (28) | 100/258 (39) | 116/241 (48) | 117/250 (47) | 122/250 (49) | |||||
| Stage | ||||||||||
| I–II | 13/35 (37) | .017 | 16/35 (46) | .029 | 13/28 (46) | .79 | 19/32 (59) | .03 | 20/33 (61) | .15 |
| III | 26/61 (43) | 33/61 (54) | 25/57 (44) | 36/59 (61) | 33/59 (56) | |||||
| IV | 64/253 (25) | 91/252 (36) | 114/234 (49) | 109/246 (44) | 113/246 (46) | |||||
| Degree of differentiation | ||||||||||
| Well-differentiated | 43/137 (31) | .47 | 54/138 (39) | .7 | 55/125 (44) | .35 | 65/134 (48) | .25 | 58/135 (43) | .18 |
| Moderately differentiated | 36/139 (26) | 54/139 (39) | 67/128 (52) | 61/138 (44) | 75/140 (54) | |||||
| Poorly differentiated | 24/73 (33) | 32/72 (42) | 31/70 (44) | 40/71 (56) | 37/71(52) | |||||
| Recurrence | ||||||||||
| No | 45/133 (34) | .18 | 63/133 (47) | .043 | 58/117 (50) | .64 | 69/127 (54) | .11 | 71/128 (56) | .07 |
| Yes | 58/216 (27) | 67/215 (36) | 94/202 (46) | 95/210 (45) | 95/210 (45) | |||||
| Total | 103/349 (29.5) | 130/348 (37) | 152/319 (47.5) | 164/337 (49) | 166/338 (49) |