Fig. 3.

Phenotypic and functional properties of CD8⁺ T cells by Lauren subtypes. a Flow cytometrical analysis of effector molecules CD107a, GZMB, PRF1 and IFN-γ expression on CD8⁺ T cells from intestinal (n = 23) and diffuse type (n = 20) gastric cancer tissues. b Flow cytometrical analysis of effector molecules PD-1, CTLA-4, TIM-3 and LAG-3 expression on CD8⁺ T cells from intestinal (n = 23) and diffuse type (n = 20) gastric cancer tissues. Data are represented as mean ± SD and P values are calculated using unpaired two-tailed t test. GZMB granzyme B, IFN-γ interferon gamma, PRF1 perforin, PD-1 programmed cell death 1, CTLA-4 cytotoxic T-lymphocyte associated protein 4, TIM-3 T cell immunoglobulin domain and mucin domain 3, LAG-3 lymphocyte activation gene-3, n.s no significance