. 2020 Feb 26;69(6):1087–1099. doi: 10.1007/s00262-020-02529-4

Table 1.

Correlations between PD-1, PD-L1 and CTLA-4 Proteins with clinicopathological parameters in primary retinoblastoma Cases

Pathological parameters N: 144	PD-1			PD-L1			CTLA-4
Pathological parameters N: 144	Negative N: 115	Positive N: 29	p value	Negative N: 98	Positive N: 46	p value*	Negative N: 91	Positive N: 53	p value*
Sex									0.848
Male (83)	46	15	0.256	69	14	0.254	53	30
Female (61)	69	14		46	15		38	23
Age									0.847
< 2 years (80)	69	11	0.033	69	11	0.033	50	30
> 2 years (64)	46	18		46	18		41	23
Laterality									0.245
Unilateral (121)	95	26	0.355	95	26	0.355	74	47
Bilateral (23)	20	3		20	3		17	6
Grouping									0.038
Group D-A (10)	7	3	0.421	6	4	0.726	3	7
Group E (134)	108	26		92	42		88	46
Staging									0.001
T₁N₀M₀ (68)	64	4	0.001	52	16	0.041	56	12
T2aN₀M₀–T4bN₀M₀ (76)	51	25		46	30		35	41
Differentiation									0.612
WDRB(19)	16	3	0.612	14	5	0.572	13	6
PDRB (125)	99	26		84	41		78	47
Necrosis									0.919
No (78)	78	0	0.001	56	22	0.295	49	29
Yes (66)	37	29		42	24		42	24
Calcification									0.589
No (80)	63	17	0.710	55	25	0.842	49	31
Yes (64)	52	12		43	21		42	24
Massive choroidal invasion									0.001
No (103)	91	16	0.008	82	25	0.001	85	22
Yes (37)	24	13		16	21		6	31
AC invasion									0.228
No (135)	110	25	0.060	94	41	0.117	87	48
Yes (9)	5	4		4	5		4	5
Scleral invasion									0.715
No (132)	108	24	0.052	91	41	0.451	84	48
Yes (12)	7	5		7	5		7	5
Iris & CB invasion									0.182
No (131)	107	24	0.084	92	39	0.076	85	46
Yes (13)	8	5		6	7		6	7
Resected margin of ON invasion									0.010
No (80)	71	9	0.003	59	21	0.101	58	22
Yes (64)	44	20		39	25		33	31
Tumor invasion/HRFs									0.001
No (66)	66	1	0.001	53	13	0.004	55	12
Yes (78)	49	28		45	33		36	41

^* Bold signifies statistical significant value