. 2020 Feb 26;69(6):1087–1099. doi: 10.1007/s00262-020-02529-4

Table 2.

Correlations between PD-1, PD-L1 and CTLA-4 Proteins with clinicopathological parameters in chemoreduced retinoblastoma Cases

Pathological parameters N: 118	PD-1			PD-L1			CTLA-4
Pathological parameters N: 118	Negative N: 70	Positive N: 48	p value*	Negative N: 96	Positive N: 22	p value*	Negative N: 80	Positive N: 38	p value*
Sex									0.735
Female (44)	30	14	0.131	59	15	0.557	51	23
Male (74)	40	34		37	7		29	15
Age									0.360
< 2 years (60)	39	21	0.202	48	12	0.700	43	17
> 2 years (58)	31	27		48	10		37	21
Laterality									0.842
Unilateral (73)	44	29	0.789	61	12	0.433	49	24
Bilateral (45)	26	19		35	10		31	14
Grouping									0.145
Group E (109)	65	44	1.000	90	19	0.365	76	33
Group D-A (9)	5	4		6	3		4	5
Staging									0.001
T₁–T2b(82)	52	30	0.172	71	11	0.028	64	18
T3a–T4(36)	18	18		25	11		16	20
Differentiation									0.279
WDRB (15)	12	3	0.081	15	0	0.047	12	3
PDRB (103)	58	45		81	22		68	35
Necrosis									0.086
No (78)	47	31	0.773	64	14	0.787	57	21
Yes (40)	23	17		32	8		23	17
Calcification									0.545
No (45)	27	18	0.906	36	9	0.767	32	13
Yes (73)	43	30		60	13		48	25
Massive choroidal invasion									0.001
No (95)	61	34	0.032	82	13	0.007	73	22
Yes (23)	9	14		14	9		7	16
AC invasion									0.703
No (113)	67	46	0.975	94	19	0.015	77	36
Yes (5)	3	2		2	3		3	2
Scleral invasion									0.001
No (94)	62	32	0.004	81	13	0.008	73	21
Yes (24)	8	16		15	9		7	17
Iris invasion									0.952
No (112)	69	43	0.061	92	20	0.343	76	36
Yes (6)	1	5		4	2		4	2
Resected margin of ON invasion									0.109
No (94)	59	35	0.132	77	17	0.758	67	27
Yes (24)	11	13		19	5		13	11
Phthisical eye									0.579
No (102)	63	39	0.173	83	19	1.000	68	34
Yes (16)	7	9		13	3		12	4
Foamy macrophages									0.159
No (93)	66	27	0.001	75	18	0.703	66	27
Yes (25)	4	21		21	4		14	11
Retinal gliosis									0.930
No (106)	64	42	0.488	87	19	0.551	63	43
Yes (12)	6	6		9	3		7	5
Fibrosis									0.609
No (105)	63	42	0.670	86	19	0.664	62	43
Yes (13)	7	6		10	3		8	5
Cholesterol clefts									0.505
No (109)	68	41	0.018	90	19	0.238	65	36
Yes (9)	2	7		6	3		5	2
Extrascleral invasion									0.061
No (108)	68	40	0.019	89	19	0.343	76	32
Yes (10)	2	8		7	3		4	6
CB invasion									0.361
No (111)	67	44	0.361	90	21	0.760	75	36
Yes (7)	3	4		6	1		5	2

^* Bold signifies statistical significant value