TABLE 1.
Summary of Rex mutant proteinsa
| Mutant | Positions (aa)b | Mutations | Domain affectedc | Reference |
|---|---|---|---|---|
| RexM6 | 5, 60 | Y,I→D,L | M | 71 |
| RexM7 | 64, 65 | Y,W→D,L | M | 71 |
| RexΔ5 | 58–70 | Deleted | M | 92 |
| RexIW18 | 86–104 | Deleted | AD | 93 |
| RexM13 | 119–121 | T,F,H→D,L | M | 71 |
| RexID1 | 99–105 | Deleted | M | This study |
| RexID2 | 99–133 | Deleted | M | This study |
| RexID3 | 104–126 | Deleted | M | This study |
| RexID4 | 110–126 | Deleted | M | This study |
| RexID5 | 118–126 | Deleted | M | This study |
| RexID6 | 125–133 | Deleted | M | This study |
a
Variants expressing leucine zipper-Rex (Zip-Rex) fusion proteins were constructed by fusing sequences encoding the GCN4 leucine zipper element (42) in frame in front of the respective rex gene.
b
Positions mutated within the 189-aa HTLV-1 Rex protein.
c
M, multimerization domain; AD, activation-effector domain.