Table 3.

Treatment-related adverse events

	Combination group (n = 22)		Chemotherapy group (n = 36)
	Grade 1–4	Grade 3–4	Grade 1–4	Grade 3–4
Any terma	19 (86.4%)	7 (31.8%)	30 (83.3%)	6 (16.7%)
Nausea	6 (27.3%)	1 (4.5%)	15 (41.7%)	1 (2.8%)
Diarrhea	1 (4.5%)	0	0	0
Fever	1 (4.5%)	0	0	0
Fatigue	1 (4.5%)	0	0	0
Anemia	1 (4.5%)	0	4 (11.1%)	0
Creatinine	0	0	2 (5.6%)	0
Skin rash	0	0	1 (2.7%)	0
Neurotoxicity	0	0	8 (22.2%)	1 (2.8%)
Pulmonitis	1 (4.5%)	0	0	0
AST elevation	2 (4.5%)	0	0	0
ALT elevation	0	0	0	0
Thrombocytopenia	5 (22.7%)	2 (9.1%)	3 (8.3%)	2 (5.6%)
Leukopenia	1 (9.1%)	0	0	0
Neutropenia	9 (40.9%)	3 (13.6%)	22 (61.1%)	3 (8.3%)

AST aspartate aminotransferase, ALT alanine aminotransferase

^aListed are all adverse events that occurred during the whole treatment process regardless of attribution to any treatment regimens