Fig. 2.

CD4⁺ T-cell responses against mutant CALR epitopes in cells from healthy individuals with a low CALR-mutant allelic burden. a Cytokine release in CD4⁺-gated T cells from a healthy individual with a low CALR-mutant allelic burden (GESUS1) stimulated with (left) CALRLong1, (middle) CALRLong2, or (right) CALRLong4. b Cytokine release in CD4⁺-gated T cells from a healthy individual with a low CALR-mutant allelic burden (GESUS4), stimulated with (left) CALRLong4, or (right) CALRLong36. Percentages indicate the proportion of cytokine-positive cells among all CD3⁺, CD4⁺-gated cells