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. Author manuscript; available in PMC: 2024 Aug 2.
Published in final edited form as: Cancer Immunol Res. 2024 Feb 2;12(2):261–274. doi: 10.1158/2326-6066.CIR-23-0127

Figure 7. Proposed mechanism of action of CARG-2020.

Figure 7.

top panel, Control no treatment ovarian tumors are “cold” and express/secrete IL17 and PD-L1 leading to differentiation of pro-tumor M2 macrophages, which inhibit the expansion of cytotoxic CD8+ T cells; bottom panel, CARG-2020, by expressing shRNA for PD-L1 and dominant negative for IL17, in addition to promoting the secretion of IL12, shifts the environment to a “hot” tumor and promotes the differentiation of antigen presenting cells and consequently expansion of cytotoxic CD8+ T cells.