Fig. 2.

The association between disease-free survival (DFS) and cyto-HMGB1 and/or PD-1+ TILs in LARC. a Kaplan–Meier curves show that cyto-HMGB1 within the tumor microenvironment is associated with 3-year DFS (p = 0.0211). b Kaplan–Meier curves show that PD-1+ TILs within the tumor microenvironment is associated with 3-year DFS (p = 0.0242). c Kaplan–Meier curves show that the level of cyto-HMGB1 and/or PD-1+ TILs within the tumor microenvironment is associated with 3-year DFS (p = 0.008). d ROC curves show sensitivity/specificity for predicting clinical outcome in LARC patients receiving neoCRT using the level of cyto-HMGB1 and/or PD-1+ TILs