Fig. 1.
Analysis of sCTLA-4 serum levels in healthy controls and IPI-treated MM patients classified according to the best overall response: irPR/irCR, irSD, irPD. sCTLA-4 levels were evaluated by ELISA testing in duplicate wells. Results were expressed as sCTLA-4 concentrations (pg × 103/ml); the horizontal lines in each column represent median values of each subgroup. To point out the difference between median sCTLA-4 levels, only data in the range 0.00–2.25 pg × 103/ml were plotted. irPR/irCR immune-related partial/complete response, irSD immune-related stable disease, irPD immune-related progressive disease