Table 3.

Multivariate Cox regression analysis for DFS and OS of adenocarcinoma-of-the-AOV patients

Variable	Category	DFS			OS
		HR	95% CI	p value	HR	95% CI	p value
Model I
Age, years	Continuous variable	1.01	0.98–1.03	0.717	1.01	0.98–1.05	0.368
Sex	Female vs. male (Ref.)	1.04	0.6–1.81	0.876	0.8	0.43–1.48	0.483
AJCC stagea	IIB ~ IV vs. IA ~ IIA (Ref.)	5.05	2.78–9.17	< 0.001	5.3	2.73–10.3	< 0.001
Tumoral PD-L1	Positive vs. negative (Ref.)	1.77	1.01–3.07	0.045	1.99	1.07–3.72	0.030
Model II
Age, years	Continuous variable	1.01	0.98–1.04	0.535	1.02	0.99–1.06	0.198
Sex	Female vs. male (Ref.)	1.08	0.63–1.88	0.772	0.85	0.46–1.58	0.608
AJCC stagea	IIB ~ IV vs. IA ~ IIA (Ref.)	5.27	2.92–9.48	< 0.001	5.39	2.8–10.36	< 0.001
Intratumoral CD8+	High vs. low (Ref.)	0.47	0.24–0.89	0.022	0.58	0.29–1.16	0.125

Statistically significant values are in bold (p value < 0.05)

AJCC American Joint Committee on Cancer, DFS disease-free survival, OS overall survival

^aTumors were staged according to criteria of the Seventh American Joint Committee on Cancer (AJCC) staging system