Table 1.
Demographic, clinical, and tumor characteristics of patients with intrahepatic cholangiocarcinoma
| Patient demographics | Derivation cohort (n = 176) | Validation cohort (n = 104) | P value |
|---|---|---|---|
| Age, year | |||
| < 60 | 99 (56.3%) | 54 (51.9%) | 0.56 |
| ≥ 60 | 77 (43.8%) | 50 (48.1%) | |
| Sex (male), n (%) | 101 (57.4%) | 72 (69.2%) | 0.07 |
| Etiology | |||
| HBV | 74 (42.1%) | 44 (42.3%) | 0.89 |
| HCV | 2 (1.1%) | 2 (1.9%) | |
| Others | 100 (56.8%) | 58 (55.8%) | |
| Liver cirrhosis, yes (%) | 37 (21.0%) | 33 (31.73%) | 0.06 |
| AFP, ng/mL | 2.7 (1.8, 4.6) | 2.8 (2.0, 5.0) | 0.31 |
| CEA, μg/mL | 2.3 (1.4, 4.6) | 2.4 (1.4, 3.7) | 0.94 |
| CA19-9, U/ml | 37.7 (13.4, 372.2) | 37.9 (17.3, 137.6) | 0.86 |
| Albumin, g/L | 43.0 (40.0, 45.0) | 43.5 (39.8, 46) | 0.79 |
| Bilirubin, μmol/L | 11.7 (8.8, 15.3) | 12.1 (9.2, 16.5) | 0.45 |
| ALT, IU/L | 19.0 (13.8, 32.0) | 25.0 (16.0, 42.3) | 0.02 |
| GGT, U/L | 47.0 (29.0, 92.0) | 55.0 (33.8, 107.0) | 0.38 |
| Platelets, 103/μL | 177.5 (141.5, 218.0) | 190 (137.8, 216.3) | 0.79 |
| Tumor nodularities, n (%) | |||
| 1 | 149 (84.7%) | 81 (77.9%) | 0.16 |
| 2 | 14 (8.0%) | 8 (7.7%) | |
| ≥ 3 | 13 (7.4%) | 15 (14.4%) | |
| Tumor diameter, cm | 6.0 (4.0, 8.0) | 6.5 (4.9, 9.0) | 0.29 |
| Tumor differentiation | |||
| I–II | 121 (68.8%) | 70 (67.3%) | 0.91 |
| III–IV | 55 (31.3%) | 34 (32.3%) | |
| Vascular invasion (yes), n (%) | 8 (4.6%) | 6 (5.8%) | 0.86 |
| Lymphoid metastasis (yes), n (%) | 8 (4.6%) | 9 (8.7%) | 0.26 |
| Direct invasion and local extrahepatic metastasis (yes), n (%) | 2 (1.1%) | 0 (0.0%) | 0.53 |
| Resection type, n (%) | |||
| Minor resection | 105 (59.7%) | 61 (58.7%) | 0.48 |
| Major resection | 71 (40.3%) | 43 (41.3%) | |
| Bleeding volume, ml | 200 (100, 400) | 200 (100, 400) | 0.57 |
| Occlusion, min | |||
| < 15 min | 115 (65.3%) | 66 (63.5%) | 0.85 |
| ≥ 15 min | 61 (34.7%) | 38 (36.5%) | |
HBV hepatitis B virus, HCV hepatitis C virus, AFP α-fetoprotein, CEA carcino-embryonic antigen, CA19-9 carbohydrate antigen 19-9, ALT alanine aminotransferase, GGT γ-glutamyl transpeptidase, VI vascular invasion
Values are presented as no. (%) or median (Q1, Q3)