Fig. 4.

Axitinib synergizes with checkpoint inhibition and co-stimulatory molecules. a C57BL/6 mice bearing established LLC1 tumors were treated with the indicated agents. Animal survival is depicted as pooled data from two independent experiments (n = 11–12). b Cancer-free animals from a were re-challenged with the same tumor cells, injected into the contralateral flank. Naïve mice (n = 6) were used as control. c C57BL/6 mice bearing established MC38 tumors were treated with the indicated agents. Animal survival is depicted as pooled data from two independent experiments (n = 12). d Cancer-free animals from c were re-challenged with the same tumor cells into the contralateral flank. Naïve mice (n = 6) were used as control. Data are presented as mean ± SD