Fig. 6.

Differences in the gut microbiome prior to and during treatment with immunotherapy. a Main bacterial genera proportions prior to (Sample 1 and Sample 2) and 1 month into (Sample 3 and Sample 4) the commencement of pembrolizumab treatment. Only bacterial genera representing more than 1% of total reads on average are represented. b Bacterial family proportions pre- and post-treatment. c Bacterial phyla proportions pre- and post-treatment. d Observed sub-operational taxonomic units (sOTUs), Shannon Index, Simpson Index and Inverse Simpson Index prior to (Sample 1 and Sample 2) and 1 month into (Sample 1 and Sample 2) the commencement of pembrolizumab treatment