Fig. 2.

Correlation between CD19⁺ TIB and molecules related to antigen presentation in specimens and database. a The top 20 significant biological pathways and processes in high (n = 185) vs. low (n = 185) CD19 MIBC patients. b Volcano plot comparing genes in high (n = 185) vs. low (n = 185) CD19 MIBC patients. Genes labeled in blue, red and green represent B-cell activation, T-cell activation and antigen-presentation pathways. c Immunohistochemical staining of CD19, MHC II and CD4 on continuous tumor slices of MIBC. Scale bar = 100 µm. d–e Correlations between the density of CD19⁺ TIB and the density of CD4⁺ TIT or MHC II⁺ cells in the tumors