. 2019 Apr 17;68(6):991–997. doi: 10.1007/s00262-019-02340-w

Table 5.

Correlation of immunohistochemical biomarkers of bladder cancer

Markers		Spearman’s rho	p values
CD3	CD4	0.355*	0.011
	CD8	0.263	0.065
	CD56	0.156	0.279
	LAG3	− 0.080	0.580
	TIM3	0.357*	0.011
	PD-1	0.152	0.291
	PDL1	0.177	0.223
CD4	CD8	0.268	0.060
	CD56	0.082	0.571
	LAG3	0.284*	0.045
	TIM3	0.001	0.996
	PD-1	0.058	0.688
	PDL1	− 0.093	0.525
CD8	CD56	− 0.031	0.830
	LAG3	− 0.108	0.454
	TIM3	0.112	0.438
	PD-1	0.428*	0.002
	PDL1	0.366*	0.010
CD56	LAG3	0.144	0.317
	TIM3	− 0.022	0.878
	PD-1	0.288*	0.042
	PDL1	0.285*	0.047
LAG3	TIM3	0.152	0.292
	PD-1	0.030	0.837
	PDL1	− 0.128	0.382
TIM3	PD-1	0.211	0.141
TIM3	PDL1	0.218	0.133
PD-1	PDL1	0.232	0.109

Spearman rho to determine correlation and p < 0.5 used to determine significance. *Significant results. All significant correlations were positive correlations