Table 3.

Univariate and multivariate analyses of prognostic factors for metastasis-free survival (n = 83) (a) and recurrence-free survival (n = 74) (b) in all histological cases

	Univariate analysis	Multivariate analysis
	P	HR	95% CI	P
(a) Metastasis-free survival (n = 83)
Age (<65 vs. ≥65 years)	0.718
Gender (male vs. female)	0.453
Histological type (ccRCC vs. non-ccRCC)	0.466
pT stage (T1/2 vs. T3/4)	<0.001	5.814	1.391–24.305	0.016
Fuhrman grade (1, 2 vs. 3, 4)	<0.001			0.119
INF (α vs. β)	<0.001
Lymphovascular invasion (no vs. yes)	<0.001
Immunological classification (Group I, II vs. Group III)	0.001	0.449	0.243–0.832	0.011
NLR (<2.4 vs. ≥2.4)	<0.001
PLR (<1.8 vs. ≥1.8)	<0.001
Hyponatremia (≥138 vs. <138 mEq/L)	<0.001
Modified Glasgow Prognostic Score (0 vs. 1, 2)	<0.001	3.247	1.071–9.843	0.037
(b) Recurrence-free survival (n = 74)
Age (< 65 vs. ≥65 years)	0.267
Gender (male vs. female)	0.982
Histological type (ccRCC vs. non-ccRCC)	0.414
pT stage (T1/2 vs. T3/4)	<0.001			0.915
Fuhrman grade (1, 2 vs. 3,4)	<0.001			0.912
INF (α vs. β)	<0.001
Lymphovascular invasion (no vs. yes)	<0.001
Immunological classification (Group I, II vs. Group III)	0.041	0.475	0.238–0.948	0.035
NLR (<2.4 vs. ≥2.4)	0.019
PLR (<1.8 vs. ≥1.8)	0.009			0.922
Hyponatremia (≥138 vs. <138 mEq/L)	<0.001
Modified Glasgow Prognostic Score (0 vs. 1, 2)	0.001

Bold values were defined as p <0.05

HR hazard ratio, CI confidence interval, ccRCC clear cell renal cell carcinoma, INF infiltration, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio