Fig. 4.

Sex-specific effects of vitamin D3 on NK cell-mediated ADCC In contrast to female volunteers, where 25-OH-D3 substitution resulted in a significant increase of rituximab-dependent ADCC activity (a), there was only a trend in males (b). The same was observed for obinutuzumab-mediated ADCC in females (c) and males (d). Further substitution to 92.8 ng/ml led to a significantly decreased ADCC in females compared to the maximum (p ≤ 0.02), irrespective of the antibody—antibody concentrations 0.1 µg/ml; E:T ratio 2.5:1