Fig. 4.

In vivo anti-tumour effect of CQ, CDDP and combined treatment. a Tumour growth curves by various treatments in Hep-2 tumour-bearing mice (n = 8). **p < 0.005 (CQ group versus PBS group, CQ + CDDP group versus CDDP group). b Tumour weights of different group at the end of treatments. **p < 0.005 (CQ group versus PBS group), ***p < 0.001 (CQ + CDDP group versus CDDP group). c PCNA analysis and TUNEL analysis of tumour tissues after treatment. The PCNA-positive proliferating cells are stained brown; TUNEL-positive cells are green. Scale bar was 20 μm