Fig. 1.

CD73 in hepatocellular carcinoma. a Hepatocellular carcinoma showing strong canalicular and moderate membranous and cytoplasmic staining. b Hepatocellular carcinoma comprising areas showing heterogeneous CD73 expression ranging from cytoplasmic, canalicular, and membranous expression (lower left to upper right). c Hepatocellular carcinoma mostly negative for CD73 with a cluster of CD73-positive tumor cells. d Periphery of a hepatocellular carcinoma showing strongly positive tumor cells at the interface with peritumoral fibrosis