Fig. 4.

mCelyvir treatment increases intratumoral N1/N2 neutrophils ratio and leukocyte infiltration. a Intratumoral immune infiltration was studied by flow cytometry. b, c Correlation of tumor volumes from mCelyvir-treated mice with N1/N2 ratios and N2 percentage. d, e, f IHC of CD45 + cells in tumors treated with PBS, syngeneic mCelyvir, and allogeneic mCelyvir. g Quantification of CD45 + cells in the periphery and core of the tumors. i IHC detection of adenoviral particles in treated tumors. Images correspond to representative samples. *p < 0.05, **p < 0.01 (Mann–Whitney U test)