. 2018 Mar 7;67(6):1011–1022. doi: 10.1007/s00262-018-2147-7

Table 1.

Relationship of TCGA-defined NSCLC molecular subtypes with adaptive and innate immune cell signatures of the lesions

NSCLC histotype	NSCLC molecular subtype	Immune-related gene expression signatures	Reference
SCC	Primitive (P)	TH2 signature similar to S subtype	[24]
SCC	Classical (C)	Lowest immune cell-related signatures of all SCC subtypes	[24]
SCC	Secretory (S)	Higher immune expression for adaptive and innate immune cells compared to other SCC subtypes. TH2 signature comparable to P subtype	[24]
SCC	Basal (B)	Increased representation, compared to C subtype, of signatures related to T, TH1, TH2, TH17, Tregs, CD8, CD56^dim NK cells, DC subsets, eosinophils, macrophages and neutrophils	[24]
ADC	Proximal inflammatory (PI)	Increased representation of signatures related to TH1, TH2 cells, Tregs, cytotoxic T cells, and CD56^dim NK cells compared to TRU subtype	[24]
ADC	Proximal proliferative (PP)	Lower immune expression compared to PI and TRU subtype for most cells evaluated	[24]
ADC	Terminal respiratory unit (TRU)	Increased representation of signatures related to DCs, CD56^bright NK cells, mast cells, eosinophils, B, TFH, TCM, TH17 and CD8 T cells, compared to PI subtype	[24]