. 2019 Apr 5;68(6):951–960. doi: 10.1007/s00262-019-02334-8

Table 5.

PD-L1 tumor cell and immune cell expression is associated to the importance of stromal CD8⁺ TIL

	n	PD-L1 TC (+)^a		PD-L1 TC (−)		p ^c	PD-L1 IC (+)^a		PD-L1 IC (−)		p ^c
	n	CD8⁺ TIL high^b	CD8⁺ TIL low^b	CD8⁺ TIL high^b	CD8⁺ TIL low^b	p ^c	CD8⁺ TIL high^b	CD8⁺ TIL low^b	CD8⁺ TIL high^b	CD8⁺ TIL low^b	p ^c
Adnexal carcinoma (total)	83	7	2	29	45	0.032	12	8	24	39	0.072
Sweat gland carcinoma	60	7	1	19	33	0.009	9	2	17	32	0.006
Sebaceous carcinoma	18	0	1	7	10	0.611	1	4	6	7	0.32
Trichoblastic carcinoma	5	0	0	3	2	n.a.	2	2	1	0	0.60

Bold values indicate statistically significant findings

^aPD-L1 (+) is defined as > 1% of tumor cells or immune cells demonstrating membranous expression

^bStromal CD8⁺ TILs: high TIL is defined as any with score of “moderate” or “abundant” infiltrates and low TIL is defined as those scores of “absent” or “mild” infiltrates as described in the Methods

^cp value by Fisher’s Exact text