Fig. 1.

Imatinib and nilotinib modulate DC phenotype and DC activation. Peripheral blood adhering monocytes cultured with GM-CSF and IL-4 were exposed to imatinib or nilotinib (1 and 3 µM) for 7 days and incubated with LPS as maturation stimulus 24 h before cell harvest. Effect of TKI on DC phenotype a regarding size and granularity and b by expression intensity was analyzed by FACS and compared to the vehicle control DMSO (white column). Results of pooled data of at least 21 donors (range n = 21–36) are shown