Fig. 5.

Effects of TKI on DC stimulatory function. The ability of human DCs, treated with imatinib or nilotinib in different concentrations and activated with LPS on day 6, to prime allogeneic T-cell responses in vitro was assessed using a MLR assay. Irradiated stimulator DCs were cultured with responding allogeneic PBMCs. Tritium-labeled thymidine incorporation was measured 5 days later. White column represents DMSO as vehicle control. cpm: counts per minute