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. 2019 Sep 27;68(10):1649–1660. doi: 10.1007/s00262-019-02403-y

Fig. 5.

Fig. 5

A schematic illustration of this study. The expression of PTPN3 was increased by signaling from CD3. The inhibition of PTPN3 led to the further activation of lymphocytes, including their proliferation, migration, and cytotoxicity, through the augmentation of phosphorylation of ZAP70, LCK, and ERK1/2