Table 1.
Univariate and multivariate analyses
| Univariate | DFS | OS | ||||
|---|---|---|---|---|---|---|
| p | Hazard ratio | 95.0% CI for exp (B) (range) | p | Hazard ratio | 95.0% CI for exp (B) (range) | |
| Molecular subtypes | 0.001 | 1.555 | 1.197–2.019 | 0.008 | 1.650 | 1.130–2.409 |
| Early advanced stage | 0.001 | 4.332 | 1.837–10.212 | 0.006 | 17.564 | 2.293–134.540 |
| T status | 0.000 | 2.988 | 1.771–5.038 | 0.000 | 4.041 | 2.003–8.153 |
| N status | 0.000 | 2.168 | 1.467–3.205 | 0.000 | 3.229 | 1.844–5.654 |
| Grade | 0.188 | 1.559 | 0.805–3.019 | 0.036 | 3.317 | 1.083–10.160 |
| Hormone receptors | 0.003 | 0.323 | 0.152–0.689 | 0.010 | 0.249 | 0.086–0.719 |
| HER-2/neu | 0.591 | 1.247 | 0.564–2.758 | 0.539 | 0.670 | 0.187–2.403 |
| Reinforced signatures | 0.001 | 3.773 | 1.675–8.496 | 0.004 | 9.206 | 2.039–41.567 |
| Multivariate | DFS | OS | ||||
|---|---|---|---|---|---|---|
| p | Hazard ratio | 95.0% CI for exp (B) (range) | p | Hazard ratio | 95.0% CI for exp (B) (range) | |
| 2. Model before stepwise selection | ||||||
| Molecular subtypes | 0.022 | 2.092 | 1.115–3.924 | 0.196 | 2.038 | 0.692–5.998 |
| Early–advanced stage | 0.415 | 1.984 | 0.382–10.299 | 0.033 | 20.878 | 1.280–340.628 |
| T status | 0.049 | 2.475 | 1.004–6.101 | 0.662 | 1.331 | 0.369–4.802 |
| N status | 0.654 | 1.162 | 0.602–2.44 | 0.743 | 1.152 | 0.495–2.78 |
| Grade | 0.387 | 0.693 | 0.302–1.591 | 0.706 | 1.378 | 0.261–7.276 |
| Hormone receptors | 0.562 | 1.684 | 0.290–9.789 | 0.815 | 0.698 | 0.035–14.106 |
| HER-2/neu | 0.756 | 0.847 | 0.298–2.407 | 0.016 | 0.140 | 0.028–0.690 |
| Reinforced signatures | 0.009 | 3.450 | 1.366–8.708 | 0.014 | 11.026 | 1.631–74.533 |
| 2. Model after stepwise selection | ||||||
| Molecular subtypes | 0.000 | 1.685 | 1.268–2.241 | 0.000 | 2.432 | 1.528–3.871 |
| Early–advanced stage | – | – | – | 0.002 | 37.148 | 3.808–362.371 |
| T status | 0.000 | 3.522 | 1.774–6.993 | – | – | – |
| HER-2/neu | – | – | – | 0.012 | 0.158 | 0.037–0.666 |
| Reinforced signature | 0.009 | 2.981 | 1.307–6.802 | 0.003 | 12.583 | 2.362–67.024 |
All categorical covariates were transformed into numeric codes as follows: early–advanced stage (I–IIA; 1, IIB, IIIA, III3; 2), T status (T1; 1, T2; 2, T3; 3), N stage (N0; 0, N1; 1, N2; 2, N3; 3), grade (G1; 1, G2; 2, G3; 3), hormone receptors (neg; 0, pos; 1), HER-2/neu (neg; 0, pos; 1), reinforced signatures (RFCIS; 1, R UCIS; 2), molecular subtypes (Lum A; 1, Lum B; 2; luminal B/Her2 +, 3, HER2 +, 4 TNBC, 5)
CI confidence interval, HR hazard ratio