. 2019 Jun 13;68(7):1157–1169. doi: 10.1007/s00262-019-02349-1

Table 1.

The correlations between miR-455-5p, galectin-9, TILs and clinicopathological features of skull base chordoma patients

Clinicopathological factors	TIM3⁺ TILs			Tumor galectin-9 expression			Tumor miR-455-5p expression			CD8⁺ TILs			FOXp3⁺ TILs
Clinicopathological factors	No. of patients (n = 93)	Mean ± SD	p values	Negative (n = 23)	Positive (n = 70)	p values	No. of patients (n = 93)	Mean ± SD	p values	No. of patients (n = 93)	Mean ± SD	p values	No. of patients (n = 93)	Mean ± SD	p values
Age (years)
≤ 50	45	231.5 ± 51.6	0.283	9	36	0.433	45	4.38 ± 2.39	0.679	45	367.3 ± 44.2	0.908	45	168.5 ± 46.2	0.751
> 50	48	245.5 ± 54.2	0.283	14	34	0.433	48	4.16 ± 2.64	0.679	48	366.2 ± 47.1	0.908	48	165.8 ± 45.9	0.751
Sex
Male	53	232.3 ± 53.9	0.278	13	40	1.000	53	4.04 ± 2.57	0.297	53	369.9 ± 47.2	0.439	53	170.1 ± 46.1	0.475
Female	40	247.2 ± 51.5	0.278	10	30	1.000	40	4.59 ± 2.39	0.297	40	362.5 ± 43.4	0.439	40	163.2 ± 45.8	0.475
Tumor size (cm)
≤ 4	37	232.4 ± 53.1	0.947	11	26	0.508	37	3.88 ± 2.51	0.059	37	366.8 ± 42.1	0.988	37	168.4 ± 48.2	0.827
> 4	56	243 ± 53.2	0.947	12	44	0.508	56	4.88 ± 2.38	0.059	56	366.6 ± 47.9	0.988	56	166.3 ± 44.6	0.827
Location
Superior clivus	45	243.2 ± 51.8	0.641	12	33	0.677	45	4.20 ± 2.55	0.934	45	407.6 ± 45.5	0.206	45	178.8 ± 31.8	0.070
Middle clivus	30	254.3 ± 46.9		8	22		30	4.11 ± 2.49		30	417.4 ± 41.3		30	172.5 ± 29.7
Inferior clivus	18	255.4 ± 56.0		3	15		18	4.74 ± 2.46		18	393.8 ± 44.9		18	166.5 ± 20.2
Invasion condition
Yes	68	247.3 ± 51.	0.010	12	56	0.019	68	3.91 ± 2.57	0.017	68	364.9 ± 44.3	0.534	68	165.5 ± 47.2	0.814
No	25	215.6 ± 52.1	0.010	11	14	0.019	25	5.29 ± 1.99	0.017	25	371.6 ± 49.2	0.534	25	169.0 ± 42.7	0.814
Preoperative recurrence
Yes	76	239.1 ± 52.4	0.893	16	60	0.153	76	4.37 ± 2.43	0.517	76	367.8 ± 44.8	0.616	76	167.5 ± 45.8	0.891
No	17	237.2 ± 57.9	0.893	7	10	0.153	17	3.98 ± 2.72	0.517	17	361.7 ± 49.4	0.616	17	165.7 ± 47.2	0.891
Rate of resection
> 90%	50	227.9 ± 50.8	0.683	10	40	0.368	50	4.19 ± 2.20	0.615	50	362.4 ± 46.4	0.326	50	165.5 ± 48.4	0.720
≤ 90%	43	251.5 ± 53.6	0.683	13	30	0.368	43	4.47 ± 2.27	0.615	43	372.7 ± 44.4	0.326	43	168.9 ± 43.1	0.720
KPS
< 80	38	252.5 ± 54.9	0.037	2	36	0.001	38	4.41 ± 2.59	0.538	38	363.9 ± 43.6	0.629	38	162.7 ± 44.0	0.439
≥ 80	55	229.3 ± 50.2	0.037	21	34	0.001	55	4.08 ± 2.37	0.538	55	368.6 ± 47.1	0.629	55	170.2 ± 47.2	0.439
Histopathology
Conventional	74	238.8 ± 52.1	0.996	18	56	1.000	74	4.51 ± 2.53	0.072	74	367.9 ± 45.5	0.628	74	168.3 ± 45.9	0.619
Chondroid	19	237.9 ± 58.4	0.996	5	14	1.000	19	3.36 ± 2.18	0.072	19	362.1 ± 46.4	0.628	19	162.4 ± 46.6	0.619