Fig. 4.

CP-870,893 prevents the growth of the human breast tumor cell line, BT 474 in the presence of human T cells and mDCs. BT474 tumor cells were administered s.c. along with human T cells and mDCs. a CP-870,893 was administered i.p. at the time of tumor challenge. Each data point refers to the tumor size of an individual animal measured on day 53 after challenge, a time when control animals reach a tumor size where they were euthanized. The horizontal lines represent the mean tumor size. b CP-870,893 was administered at a dose of 1.0 mg/kg once tumors reached a size of 100 mm². Each data point refers to the tumor size of an individual animal measured on day 52 after challenge, a time when control animals reach a tumor size where they were euthanized. The horizontal lines represent the mean tumor size for all animals in that group