Table 3.
Association of genotypes with the occurrence of precancerous lesions
| SNP | Model | Genotype | Patient (n, %) | Control (n, %) | OR (95% CI) | P value |
|---|---|---|---|---|---|---|
| rs10815225 | Codominant | G/G | 133 (85.8) | 411 (82.2) | 1 | 0.11 |
| G/C | 21 (13.6) | 89 (17.8) | 0.73 (0.44–1.22) | |||
| C/C | 1 (0.6) | 0 (0) | NA (0.00-NA) | |||
| Dominant | G/G | 133 (85.8) | 411 (82.2) | 1 | 0.29 | |
| G/C–C/C | 22 (14.2) | 89 (17.8) | 0.76 (0.46–1.27) | |||
| Recessive | G/G–G/C | 154 (99.3) | 500 (100) | 1 | 0.089 | |
| C/C | 1 (0.6) | 0 (0) | NA (0.00-NA) | |||
| Overdominant | G/G–C/C | 134 (86.5) | 411 (82.2) | 1 | 0.21 | |
| G/C | 21 (13.6) | 89 (17.8) | 0.72 (0.43–1.21) | |||
| rs4143815 | Codominant | C/C | 30 (19.5) | 160 (32) | 1 | 0.0013 |
| G/C | 69 (44.8) | 223 (44.6) | 1.65 (1.03–2.65) | |||
| G/G | 55 (35.7) | 117 (23.4) | 2.51 (1.51–4.15) | |||
| Dominant | C/C | 30 (19.5) | 160 (32) | 1 | 0.0021 | |
| G/C-G/G | 124 (80.5) | 340 (68) | 1.95 (1.25–3.02) | |||
| Recessive | C/C-G/C | 99 (64.3) | 383 (76.6) | 1 | 0.003 | |
| G/G | 55 (35.7) | 117 (23.4) | 1.82 (1.23–2.68) | |||
| Overdominant | C/C-G/G | 85 (55.2) | 277 (55.4) | 1 | 0.96 | |
| G/C | 69 (44.8) | 223 (44.6) | 1.01 (0.70–1.45) |
Significant results are shown in bold (P < 0.05)