Fig. 2.
Patients’ preexisting and AE37-induced in vitro and in vivo immunity in patients expressing (+) (open circles) or not expressing (−) (filled circles) the indicated HLA alleles (IFN-γ ELISPOT and DTH results are presented, respectively, in a and d for HLA-A*24, b and e for HLA-DRB1*11 and c and f for both allele expression, HLA-DRB1*11/HLA-A*24). R0: preexisting immunological responses; R6, LT, LTB: vaccine-induced immunity; see also “Materials and Methods”. Horizontal lines, median responses. g–j immune profile of patients; percentage of patients with preexisting or AE37-induced immunity above or below the respective median values (17 specific spots/106 PBMCs for IFN-γ immunity and 5 mm for DTH reactions)