Table 4.
Data obtained by FACS analysis after intracellular cytokine staining on day +100 post-transplant
| Lymphoid subpopulation | Day +100 in % (alive vs. death) | P values |
|---|---|---|
| CD3 IFNγ | 69 ± 9 vs. 31 ± 8 | 0.0004 |
| CD8 IFNγ | 50 ± 7 vs. 14 ± 5 | <0.0001 |
| CD3 CD45RO IFNγ | 89 ± 10 vs. 34 ± 6 | 0.001 |
| CD3 CD45RA IFNγ | 76 ± 12 vs. 27 ± 5 | 0.04 |
| CD3 TNFα | 62 ± 5 vs. 29 ± 8 | 0.001 |
| CD8 TNFα | 45 ± 16 vs. 15 ± 8 | 0.004 |
| CD3 CD45RO TNFα | 62 ± 6 vs. 40 ± 11 | NS (0.1) |
| CD3 CD45RA TNFα | 29 ± 9 vs. 7 ± 5 | 0.008 |
Patients who were alive on May 01, 2010 to patients who had died of progressive disease were compared. The data depict the percentage of cytokine-positive cells in the respective T-cell subpopulation. The survivors showed higher expressions of IFNγ and TNFα, especially in CD8-positive and CD45RO-positive cells than non-survivors on day +100 post-transplantation