Fig. 4.

ApoLinkerP144-expressing tumor cells triggers an antitumor immune response. a Rag-1 immune-deficient mice received subcutaneously 5 × 10⁵ MC38 Apo or MC38 ApoLinkerP144 transfected cell lines. Tumor growth was measured at regular intervals. Mean ± SEM ***P < 0.001. b NK cells from C57BL/6 mice were depleted by administration of 100 µg anti-NK1.1 antibody at days −2, 0 and 3. On day 0, 5 × 10⁵ MC38 Apo or MC38 ApoLinkerP144 transfected cell lines were inoculated subcutaneously. Tumor growth was measured at regular intervals. Mean ± SEM ***P < 0.001