Fig. 4.

Coding DNA sequence and protein sequence of variable regions of ganglidiomab. The coding DNA sequences and the protein sequences of FR 1–4 and CDR 1–3 and the leader peptide of the variable regions of heavy and light chains of ganglidiomab (blue) are aligned with sequences of 1A7 (black). Differences between the two anti-idiotypic antibodies are indicated in bold letters. The homology in coding DNA and protein sequences between ganglidiomab and 1A7 of VH are 77.46 and 71.13 % and of VL 95.74 and 93.98 %, respectively