Table 1.

Dissociation constants (KD) of ganglidiomab and 1A7 for anti-GD₂ antibodies of the 14.18 family

Ligand	Ganglidiomab KD (nM)a	1A7 KD (nM)a
14G2a	53.5 ± 19.20	5.35 ± 4.72
ch14.18	13.1 ± 4.23	3.65 ± 2.39
ch14.18-IL2	49.3 ± 23.40	1.13 ± 1.06
ch14.18-delta-CH2	23.3 ± 10.20	10.9 ± 10.30
hu14.18	10.8 ± 5.01	11.8 ± 11.70
hu14.18-IL2	13.7 ± 4.95	10.8 ± 4.97

^aDissociation constants (KD) of ligands 14G2a, ch14.18/CHO, ch14.18-IL2, ch14.18-delta-CH2, hu14.18, and hu14.18-IL2 from ganglidiomab and 1A7 were determined by surface plasmon resonance in a Biacore X100 system followed by steady-state analysis. Values are means ± SE of 3 independent experiments