Table 2.
EGCG reverses PMA-mediated IκB degradation in adherent HL-60 cells
| Gene name | Gene ID | EGCG inhibition (%) | Functional grouping |
|---|---|---|---|
| MMP9 | 4318 | 99 | Differentiation, apoptosis |
| CCR5 | 1234 | 98 | Inflammation |
| IL1RN | 3557 | 97 | Cytokines/chemokines |
| CD40 | 958 | 96 | Immune response |
| VCAM1 | 7412 | 96 | Differentiation |
| CXCL1 | 2919 | 96 | Cytokines/chemokines |
| CCL5 | 6352 | 95 | Cytokines/chemokines, development |
| FASLG | 356 | 95 | Apoptosis |
| IL1B | 3553 | 95 | Inflammation, cytokines/chemokines, |
| COX2 | 5743 | 95 | Inflammation, apoptosis |
| CXCL2 | 2920 | 94 | Cytokines/chemokines |
| IL1R2 | 7850 | 94 | Immune response |
| TNF | 7124 | 94 | Inflammation, development, stress response |
| CXCL10 | 3627 | 94 | Inflammation |
| MITF | 4286 | 93 | Differentiation, apoptosis |
| PDGFB | 5155 | 92 | Stress response |
| IL2RA | 3559 | 91 | Inflammation |
| CCL2 | 6347 | 90 | Immune response, cytokines/chemokines |
| CXCL9 | 4283 | 90 | Inflammation |
Serum-starved HL-60 cells were treated with either 30 μM EGCG or a combination of 3 nM PMA and 30 μM EGCG for 18 h. Total RNA was isolated from EGCG-treated cells that remained in suspension and from PMA-treated cells that adhered to the flasks (macrophage-differentiated cells). The identity of only those genes which expression was inhibited by 90 % and more is shown and is extracted from Fig. 2b. Data are representative from two independent arrays. Italized data were further confirmed at the protein and/or activity level