Fig. 5.

Th1 and Th17 cytokine profiles are associated with DTH⁺ reactions and prolonged patient survival, while TH3 profile is associated with immunological unresponsiveness. Fold change ratio obtained calculating the difference between pre- and post-vaccine values for each patient for Tr1 (CD4⁺IL-10⁺), Treg (CD4⁺CD25⁺Foxp3⁺), TH3 (CD4⁺TGF-β⁺), TGF-βs (soluble TGF-β), Th1 (CD4⁺ IFN-γ⁺), Th17 (CD4⁺ IL-17⁺) are showed for a DTH⁺ and b DTH⁻ patients. Statistical analyzes were performed using non-paired student’s t-test (p < 0.05, **p < 0.01, ***p < 0.001)