Th1 and Th17 cytokine profiles are associated with DTH+ reactions and prolonged patient survival, while TH3 profile is associated with immunological unresponsiveness. Fold change ratio obtained calculating the difference between pre- and post-vaccine values for each patient for Tr1 (CD4+IL-10+), Treg (CD4+CD25+Foxp3+), TH3 (CD4+TGF-β+), TGF-βs (soluble TGF-β), Th1 (CD4+ IFN-γ+), Th17 (CD4+ IL-17+) are showed for a DTH+ and b DTH− patients. Statistical analyzes were performed using non-paired student’s t-test (p < 0.05, **p < 0.01, ***p < 0.001)