Fig. 1.
Promotion of tumor growth in aged mice. a Young (7 W) and aged (45 W) BALB/c mice (n = 6) were inoculated s.c. with the indicated doses of CT26 cells. Each line represents the tumor growth of an individual mouse. b A representative result of tumor growth in BALB/c mice that were injected s.c. in the right flank with 1 × 105 CT26 cells is shown. *P < 0.05, **P < 0.01. Similar results were obtained in two independent experiments. c (Left) Young (7 W) and aged (60–65 W) BALB/c mice (n = 7) were inoculated s.c. with 1 × 105 CT26 cells. *P < 0.05, **P < 0.01. Similar results were obtained in three independent experiments. (Right) On day 28, tumor weight was measured. *P < 0.05. NT no tumor