Table 1.

Cytokine concentrations in PHA-stimulated whole blood cultures of control subjects, DTC patients before and 7 days after 131-I therapy (p values indicate the significance of differences)

Cytokine	Control subjects			DTC patients before 131-I therapy			DTC patients 7 days after 131-I therapy
	Range (minimum–maximum) (pg/ml)	X ± SD (pg/ml)	Median (pg/ml)	Range (minimum–maximum) (pg/ml)	X ± SD (pg/ml)	Median (pg/ml)	Range (minimum–maximum) (pg/ml)	X ± SD (pg/ml)	Median (pg/ml)
IFN-γ	430–58,040	22,940 ± 19,182	21,774	4,468–48,490	27,343 ± 15,691	28,821	4,386–54,190	30,150 ± 16,660	28,146
IL-2	0.0–8,124	2,141 ± 3,014	694	447–10,893	4,322 ± 3,768	2,998	472–2,423	1,419 ± 656	1,308
TNF-α	0.0–849	336 ± 291	291	0.0–8,071	1,330 ± 2,732	448	194–734	360 ± 169	306
IL-4	0.0–823	286 ± 293	288	181–1,134	494 ± 312d	396	0.0–393	193 ± 170	240
IL-5	0.0–2,412	869 ± 842a	740	518–4,763	2,232 ± 1608e	1,396	0.0–2,769	826 ± 1,135	350
IL-13	0.0–1,300	460 ± 475b	419	317–2,730	1,602 ± 954f	1,783	450–1,666	709 ± 417	500
IL-10	0.0–1,415	702 ± 513	738	144–5,390	1,319 ± 1,744	643	304–2,580	770 ± 778	492
IL-9	0.0–142	42.4 ± 60.7c	0	0.0–293	125.8 ± 87.3	122	0.0–226	89.1 ± 87.9	65
IL-17	1,101–14,970	4,891 ± 4,365	4,075	976–14,983	7,743 ± 4,561	8,252	1,041–25,465	7,262 ± 8,259	3,596

^aStatistical significant difference between DTC patients before therapy and control subjects, p = 0.046

^bStatistical significant difference between DTC patients before therapy and control subjects, p = 0.012

^cStatistical significant difference between DTC patients before therapy and control subjects, p = 0.038

^dStatistical significant difference between DTC patients before and 7 days after therapy, p = 0.031

^eStatistical significant difference between DTC patients before and 7 days after therapy, p = 0.038

^fStatistical significant difference between DTC patients before and 7 days after therapy, p = 0.037