Fig. 4.

Advanced intracerebral (ic) B16-F10-luc2 melanomas followed by luciferase bioluminescence as a function of time following the implantation of 250 B16-F10-luc2 cells. a 18.75 Gy RT-only (N = 10) or b 18.75 Gy RT plus IT (N = 9) (all tumors). Each line represents one mouse. The data represent the results of a single experiment. c Survival plots for the data shown in a, b RT plus IT increases both median survival and long-term survivors compared to RT-only. Shown are the survival plots for all tumors (both >10⁶ and <10⁶ photons/min measured on day 7 following ic implantation. (Solid red 18.75 Gy RT-only, dashed green 18.75 Gy RT + IT. d Comparison of the dot plots of TTP for RT-only, RT plus IT for all tumors: RT plus IT increases TTP compared to RT alone. (Red 18.75 Gy RT-only, Green 18.75 Gy RT plus IT