Fig. 5.

Long-term surviving mouse that received 18.75 Gy RT plus IT contains residual melanin-containing cells in the brain. a Residual bioluminescence at 10 months, prior to euthanasia. b Source of bioluminescent signal is primarily in the brain. c, d, e Nests of residual melanin-producing cells stained with H&E at ×10 (c) and ×20 (d), and DAPI stained at ×20 (e). f, g, h Mouse brain with untreated, control melanoma stained with H&E at ×10 (f), ×20 (g), and DAPI stained at ×20 (h)