Table 1.
Clinical features | Glioma cases | Controls | P b | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
All | A*02:01 (+) | A*02:01 (−) | P a | All | A*02:01 (+) | A*02:01 (−) | P a | ||||||||||||||
No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | ||||||||||
Total | 150 | 100 | 24 | 16 | 126 | 84 | – | 150 | 100 | 49 | 32.7 | 101 | 67.3 | – | 0.001 | ||||||
Age | 0.509 | ||||||||||||||||||||
Mean | 47.4 | 43.8 | 47.0 | 0.208 | 46.5 | 49.6 | 46.4 | 0.139 | |||||||||||||
SD | 12.3 | 9.7 | 11.6 | 11.4 | 13.0 | 12.0 | |||||||||||||||
Sex | – | ||||||||||||||||||||
Male | 85 | 56.7 | 15 | 62.5 | 70 | 55.6 | 0.529 | 85 | 56.7 | 29 | 59.2 | 56 | 55.4 | 0.665 | |||||||
Female | 65 | 43.3 | 9 | 37.5 | 56 | 44.4 | 65 | 43.3 | 20 | 40.8 | 45 | 44.6 | |||||||||
Gliomas | |||||||||||||||||||||
Low-grade | 33 | 22 | 5 | 20.8 | 28 | 22.2 | 0.880 | – | – | – | – | – | – | – | |||||||
High-grade | 117 | 78 | 19 | 79.2 | 98 | 77.8 | – | – | – | – | – | – | |||||||||
IDH1/2 | |||||||||||||||||||||
Mutated | 51 | 34 | 9 | 37.5 | 42 | 33.3 | 0.693 | – | – | – | – | – | – | – | |||||||
Wild-type | 99 | 66 | 15 | 62.5 | 84 | 66.7 | – | – | – | – | – | – | |||||||||
MGMT | |||||||||||||||||||||
Methylated | 59 | 39.3 | 11 | 45.8 | 48 | 38.1 | 0.477 | – | – | – | – | – | – | – | |||||||
Unmethylated | 91 | 60.7 | 13 | 54.2 | 78 | 61.9 | – | – | – | – | – | – | |||||||||
IE1-72 | |||||||||||||||||||||
Positive | 117 | 78 | 6 | 25 | 111 | 88.1 | 0.001 | – | – | – | – | – | – | – | |||||||
Negative | 33 | 22 | 18 | 75 | 15 | 11.9 | – | – | – | – | – | – | |||||||||
pp65 | |||||||||||||||||||||
Positive | 99 | 66 | 6 | 25 | 93 | 73.8 | 0.001 | – | – | – | – | – | – | – | |||||||
Negative | 51 | 44 | 18 | 75 | 33 | 26.2 | – | – | – | – | – | – | |||||||||
HCMV DNA | |||||||||||||||||||||
Positive | 48 | 32 | 2 | 8.3 | 46 | 36.5 | 0.007 | – | – | – | – | – | – | – | |||||||
Negative | 102 | 68 | 22 | 91.7 | 80 | 63.5 | – | – | – | – | – | – | |||||||||
HCMV IgG | 0.602 | ||||||||||||||||||||
Positive | 112 | 74.7 | 15 | 62.5 | 97 | 77.0 | 0.135 | 108 | 72.0 | 32 | 65.3 | 76 | 75.2 | 0.203 | |||||||
Negative | 38 | 25.3 | 9 | 37.5 | 29 | 23.0 | 42 | 28.0 | 17 | 34.7 | 25 | 24.8 | |||||||||
HCMV IgM | 0.442 | ||||||||||||||||||||
Positive | 28 | 18.7 | 1 | 4.2 | 27 | 21.4 | 0.047 | 23 | 15.3 | 3 | 6.1 | 20 | 19.8 | 0.029 | |||||||
Negative | 122 | 81.3 | 23 | 95.8 | 99 | 78.6 | 127 | 84.7 | 46 | 93.9 | 81 | 80.2 |
Statistically significant P values <0.05 are italicized
aA*02:01 (+) vs A*02:01 (−)
bCases vs controls