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HLA class I abnormalities in human tumors
| Highly variable frequency in many tumors |
| Total HLA class I antigen loss (9–52%) |
| HLA class I downregulation (3–20%) |
| Selective loss or downregulation of HLA class I allospecificities (15–50%) |
| Association with disease progression |
| Tissue and/or tumor subtype specificity |
| Differentiation/cell cycle dependence |
