Table 2.
Cox proportional hazards regression analysis for overall survival from enrollment
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
| HR | 95 % CI | p | HR | 95 % CI | p | |
| Proliferating CD8+ T cells (%), high/low | 2.86 | 1.26–6.50 | 0.012 | 2.58 | 1.01–6.61 | 0.049 |
| Effector CD8+ T cells (%), high/low | 1.69 | 0.83–3.42 | 0.146 | – | – | – |
| Treg (%), high/low | 3.81 | 1.69–8.57 | 0.001 | 2.40 | 0.94–6.17 | 0.069 |
| Proliferating Treg (%), high/low | 0.73 | 0.36–1.48 | 0.377 | – | – | – |
| Gender, male/female | 0.48 | 0.18–1.25 | 0.132 | 0.70 | 0.18–2.65 | 0.594 |
| Age (years), above/below median | 1.22 | 0.60–2.47 | 0.586 | 0.84 | 0.38–1.89 | 0.662 |
| ECOG status (0, 1 or 2–3) | 2 .24 | 1.14–4.43 | 0.020 | 1.69 | 0.76–3.78 | 0.200 |
| WBC (x109/L), high/low | 2.09 | 1.02–4.29 | 0.045 | 2.41 | 0.92–6.32 | 0.075 |
| Hemoglobin (g/L), high/low | 0.7 | 0.35–1.40 | 0.309 | 0.62 | 0.26–1.48 | 0.284 |
| Platelets (x109/L), high/low | 1.04 | 0.51–2.11 | 0.912 | 0.73 | 0.31–1.69 | 0.457 |
| Diagnosis, MM/NSCLC | 0.85 | 0.41–1.78 | 0.673 | 1.55 | 0.63–3.85 | 0.344 |
All categorical covariates were transformed into numeric codes before entering into the model. Immunological variables were divided into high and low at the point demonstrating the strongest association with survival in univariate analysis (data-driven dichotomization) or the median if no significant association was found. Only those significant in univariate analysis were included in the multivariate model. Clinical variables were dichotomized at the median
Bold values denote significant associations (p < 0.05)
CI confidence interval, ECOG Eastern Cooperative Oncology Group, HR hazard ratio, WBC white blood cell count