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. 2016 Dec 3;66(3):343–354. doi: 10.1007/s00262-016-1931-5

Table 2.

Correlation between LMR and TILs/TAM ratio and clinicopathological characteristics

LMR CD45RO/CD68 ratio CD8/CD68 ratio CD4/CD68 ratio
Low High p Low High p Low High p Low High p
Age (years) 0.787 0.250 0.683 0.455
 ≤60 72 52 87 37 98 26 97 27
 >60 54 42 74 22 78 18 79 17
Gender 0.998 0.303 0.893 0.636
 Male 67 50 89 28 94 23 95 22
 Female 59 44 72 31 82 21 81 22
KPS 0.216 0.253 0.651 0.407
 <80 39 22 48 13 50 11 51 10
 ≥80 87 72 113 46 126 33 125 34
Tumor location 0.896 0.382 0.054 0.464
 Upper 16 10 21 5 21 5 23 3
 Middle 50 38 67 21 77 11 71 17
 Lower 60 46 73 33 78 28 82 24
Tumor differentiation 0.016 0.006 0.248 0.036
 Well 44 44 54 34 67 21 64 24
 Moderate 46 38 67 17 72 12 74 10
 Poor 36 12 40 8 37 11 38 10
Tumor length 0.023 0.300 0.629 0.408
 ≤4 cm 68 65 94 39 105 28 104 29
 >4 cm 58 29 67 20 71 16 72 15
Perineural invasion 0.702 0.195 0.602 1.000
 No 123 91 155 59 170 44 171 43
 Yes 3 3 6 0 6 0 5 1
Vascular invasion 0.701 0.194 0.349 0.349
 No 121 92 154 59 169 44 169 44
 Yes 5 2 7 0 7 0 7 0
Treatment 0.820 0.178 0.161
 Surgery only 61 41 77 25 85 17 84 18 0.330
 Adjuvant chemotherapy 25 21 30 16 32 14 37 9
 Adjuvant radiation 23 16 26 13 30 9 27 12
 Adjuvant chemoradiation 17 16 28 5 29 4 28 5
Recurrence 0.319 <0.001 0.130 0.016
 No 19 19 19 19 27 11 25 13
 Yes 107 75 142 40 149 33 151 31

Values in bold signify p < 0.05

LMR lymphocyte-to-monocyte ratio, TILs tumor-infiltrating lymphocytes, TAM tumor-associated macrophages